癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KLK10 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant KLK10.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | O43240 |
| Other Accession | NM_002776 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 lambda |
| Clone Names | 1G8 |
| Calculated MW | 30170 Da |
| Gene ID | 5655 |
|---|---|
| Other Names | Kallikrein-10, 3421-, Normal epithelial cell-specific 1, Protease serine-like 1, KLK10, NES1, PRSSL1 |
| Target/Specificity | KLK10 (NP_002767, 167 a.a. ~ 276 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | KLK10 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
REFERENCES
Kallikrein-related peptidase 10 (KLK10) expression and single nucleotide polymorphisms in ovarian cancer survival. Batra J, et al. Int J Gynecol Cancer, 2010 May. PMID 20686372.Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. Klein RJ, et al. Cancer Prev Res (Phila), 2010 May. PMID 20424135.Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Papageorgis P, et al. Cancer Res, 2010 Feb 1. PMID 20086175.Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma. Lu CY, et al. Genes Chromosomes Cancer, 2009 Dec. PMID 19760608.The kallikrein family of proteins as urinary biomarkers for the detection of prostate cancer. Sardana G, et al. Clin Biochem, 2009 Sep. PMID 19560453.
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