癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MAPKAPK2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant MAPKAPK2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IF, IP, E |
|---|---|
| Primary Accession | P49137 |
| Other Accession | NM_032960 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2B3 |
| Calculated MW | 45568 Da |
| Gene ID | 9261 |
|---|---|
| Other Names | MAP kinase-activated protein kinase 2, MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAP-K2, MAPKAPK-2, MK-2, MK2, MAPKAPK2 |
| Target/Specificity | MAPKAPK2 (NP_116584, 302 a.a. ~ 400 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MAPKAPK2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
REFERENCES
TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2. Gais P, et al. J Immunol, 2010 May 15. PMID 20375303.p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. Cannell IG, et al. Proc Natl Acad Sci U S A, 2010 Mar 23. PMID 20212154.MK2 signaling: lessons on tissue specificity in modulation of inflammation. Fyhrquist N, et al. J Invest Dermatol, 2010 Feb. PMID 20081887.p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity. Kumar B, et al. Cancer Res, 2010 Jan 15. PMID 20068172.The MAP kinase-activated protein kinase 2 (MK2) contributes to the Shiga toxin-induced inflammatory response. Saenz JB, et al. Cell Microbiol, 2010 Apr 1. PMID 19951368.
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