癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MARCKS Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant MARCKS.
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P29966 |
| Other Accession | NM_002356 |
| Reactivity | Human, Mouse |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2H4 |
| Calculated MW | 31555 Da |
| Gene ID | 4082 |
|---|---|
| Other Names | Myristoylated alanine-rich C-kinase substrate, MARCKS, Protein kinase C substrate, 80 kDa protein, light chain, 80K-L protein, PKCSL, MARCKS, MACS, PRKCSL |
| Target/Specificity | MARCKS (NP_002347, 2 a.a. ~ 65 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MARCKS Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
REFERENCES
MARCKS and related chaperones bind to unconventional myosin V isoforms in airway epithelial cells. Lin KW, et al. Am J Respir Cell Mol Biol, 2010 Aug. PMID 20203291.Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway. Techasen A, et al. Cancer Sci, 2010 Mar. PMID 20047593.A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. Finlayson AE, et al. PLoS One, 2009 Nov 18. PMID 19924305.Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression. Micallef J, et al. Cancer Res, 2009 Oct 1. PMID 19773446.Myristoylated alanine-rich C-kinase substrate (MARCKS) protein regulation of human neutrophil migration. Eckert RE, et al. Am J Respir Cell Mol Biol, 2010 May. PMID 19574534.
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