癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MKNK1 Antibody (monoclonal) (M14)
Mouse monoclonal antibody raised against a full length recombinant MKNK1.
- 产品详情
- 实验流程
Application 
| WB, IHC, IF |
|---|---|
| Primary Accession | Q9BUB5 |
| Other Accession | BC002755 |
| Reactivity | Human, Mouse |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2F12 |
| Calculated MW | 51342 Da |
| Gene ID | 8569 |
|---|---|
| Other Names | MAP kinase-interacting serine/threonine-protein kinase 1, MAP kinase signal-integrating kinase 1, MAPK signal-integrating kinase 1, Mnk1, MKNK1, MNK1 |
| Target/Specificity | MKNK1 (AAH02755.1, 1 a.a. ~ 465 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MKNK1 Antibody (monoclonal) (M14) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity. Goto S, et al. Biochem J, 2009 Sep 25. PMID 19650764.Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation. Wang X, et al. Mol Cell Biol, 2007 Nov. PMID 17724079.Characterization of the activity of human MAP kinase-interacting kinase Mnk1b. O'Loghlen A, et al. Biochim Biophys Acta, 2007 Sep. PMID 17590453.Elevated inorganic phosphate stimulates Akt-ERK1/2-Mnk1 signaling in human lung cells. Chang SH, et al. Am J Respir Cell Mol Biol, 2006 Nov. PMID 16763222.
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