癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MOCS3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant MOCS3.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O95396 |
| Other Accession | BC015939 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b kappa |
| Clone Names | 1C5-E8 |
| Calculated MW | 49669 Da |
| Gene ID | 27304 |
|---|---|
| Other Names | Adenylyltransferase and sulfurtransferase MOCS3 {ECO:0000255|HAMAP-Rule:MF_03049}, Molybdenum cofactor synthesis protein 3 {ECO:0000255|HAMAP-Rule:MF_03049}, Molybdopterin synthase sulfurylase, MPT synthase sulfurylase, Molybdopterin-synthase adenylyltransferase {ECO:0000255|HAMAP-Rule:MF_03049}, 27780 {ECO:0000255|HAMAP-Rule:MF_03049}, Adenylyltransferase MOCS3 {ECO:0000255|HAMAP-Rule:MF_03049}, Sulfur carrier protein MOCS2A adenylyltransferase {ECO:0000255|HAMAP-Rule:MF_03049}, Molybdopterin-synthase sulfurtransferase {ECO:0000255|HAMAP-Rule:MF_03049}, 28111 {ECO:0000255|HAMAP-Rule:MF_03049}, Sulfur carrier protein MOCS2A sulfurtransferase {ECO:0000255|HAMAP-Rule:MF_03049}, Sulfurtransferase MOCS3 {ECO:0000255|HAMAP-Rule:MF_03049}, MOCS3 {ECO:0000255|HAMAP-Rule:MF_03049} |
| Target/Specificity | MOCS3 (AAH15939, 1 a.a. ~ 460 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MOCS3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. One of the enzymes required for the biosynthesis of MoCo is molybdopterin synthase (MPT synthase). The protein encoded by this gene adenylates and activates MPT synthase. This gene contains no introns. A pseudogene of this gene is present on chromosome 14.
REFERENCES
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Schlieker CD, et al. Proc Natl Acad Sci U S A, 2008 Nov 25. PMID 19017811.A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis. Marelja Z, et al. J Biol Chem, 2008 Sep 12. PMID 18650437.The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins. Schmitz J, et al. Biochemistry, 2008 Jun 17. PMID 18491921.Site-directed mutagenesis of the active site loop of the rhodanese-like domain of the human molybdopterin synthase sulfurase MOCS3. Major differences in substrate specificity between eukaryotic and bacterial homologs. Krepinsky K, et al. FEBS J, 2007 Jun. PMID 17459099.Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry. Matthies A, et al. Biochemistry, 2005 May 31. PMID 15910006.
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