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>   首页   >   产品   >   一抗   >   其他   >   MSH6 Antibody (monoclonal) (M01)   

MSH6 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant MSH6.

     
  • 1 - MSH6 Antibody (monoclonal) (M01) AT2912a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • 1 - MSH6 Antibody (monoclonal) (M01) AT2912a
    MSH6 monoclonal antibody (M01), clone 1F2. Western Blot analysis of MSH6 expression in human kidney.
  • 3 - MSH6 Antibody (monoclonal) (M01) AT2912a
    Immunofluorescence of monoclonal antibody to MSH6 on HeLa cell . [antibody concentration 10 ug/ml]
  • 10 - MSH6 Antibody (monoclonal) (M01) AT2912a
    Detection limit for recombinant GST tagged MSH6 is approximately 1ng/ml as a capture antibody.
  • 0 - MSH6 Antibody (monoclonal) (M01) AT2912a
    Proximity Ligation Analysis of protein-protein interactions between MSH2 and MSH6 HeLa cells were stained with anti-MSH2 rabbit purified polyclonal 1:1200 and anti-MSH6 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, E
Primary Accession P52701
Other Accession NM_000179
Reactivity Human
Host mouse
Clonality monoclonal
Isotype IgG1 kappa
Clone Names 1F2
Calculated MW 152786 Da
Additional info
Gene ID 2956
Other Names DNA mismatch repair protein Msh6, hMSH6, G/T mismatch-binding protein, GTBP, GTMBP, MutS-alpha 160 kDa subunit, p160, MSH6, GTBP
Target/Specificity MSH6 (NP_000170, 931 a.a. ~ 1030 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsMSH6 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas

BACKGROUND

This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

REFERENCES

Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers. van der Post RS, et al. J Med Genet, 2010 Jul. PMID 20591884.Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Monsees GM, et al. Breast Cancer Res Treat, 2010 May 23. PMID 20496165.A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndrome. Vasen HF, et al. Gastroenterology, 2010 Jun. PMID 20206180.MutSbeta exceeds MutSalpha in dinucleotide loop repair. Kantelinen J, et al. Br J Cancer, 2010 Mar 16. PMID 20160730.

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