癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MYOC Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant MYOC.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IP, E |
|---|---|
| Primary Accession | Q99972 |
| Other Accession | BC029261 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4F8 |
| Calculated MW | 56972 Da |
| Gene ID | 4653 |
|---|---|
| Other Names | Myocilin, Myocilin 55 kDa subunit, Trabecular meshwork-induced glucocorticoid response protein, Myocilin, N-terminal fragment, Myocilin 20 kDa N-terminal fragment, Myocilin, C-terminal fragment, Myocilin 35 kDa N-terminal fragment, MYOC, GLC1A, TIGR |
| Target/Specificity | MYOC (AAH29261, 36 a.a. ~ 135 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MYOC Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.
REFERENCES
Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG. McDonald KK, et al. J Hum Genet, 2010 Jul 29. PMID 20668460.Little evidence for association of the glaucoma gene MYOC with open-angle glaucoma. Sohn S, et al. Br J Ophthalmol, 2010 May. PMID 20447966.[Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg] Motushchuk AE, et al. Genetika, 2009 Dec. PMID 20198978.Association of POAG risk factors and the Thr377Met MYOC mutation in an isolated Greek population. Wirtz MK, et al. Invest Ophthalmol Vis Sci, 2010 Jun. PMID 20107173.Variable clinical spectrum of the myocilin Gln368X mutation in a Dutch family with primary open angle glaucoma. Hogewind BF, et al. Curr Eye Res, 2010 Jan. PMID 20021252.
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