癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NBR1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant NBR1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q14596 |
| Other Accession | NM_005899 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 6B11 |
| Calculated MW | 107413 Da |
| Gene ID | 4077 |
|---|---|
| Other Names | Next to BRCA1 gene 1 protein, Cell migration-inducing gene 19 protein, Membrane component chromosome 17 surface marker 2, Neighbor of BRCA1 gene 1 protein, Protein 1A1-3B, NBR1, 1A13B, KIAA0049, M17S2 |
| Target/Specificity | NBR1 (NP_005890, 2 a.a. ~ 96 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | NBR1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.
REFERENCES
1.Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease.Rue L, Lopez-Soop G, Gelpi E, Martinez-Vicente M, Alberch J, Perez-Navarro E.Neurobiol Dis. 2013 Jan 4. pii: S0969-9961(12)00400-7. doi: 10.1016/j.nbd.2012.12.008.2.NBR1 acts as an autophagy receptor for peroxisomes.Deosaran E, Larsen KB, Hua R, Sargent G, Wang Y, Kim S, Lamark T, Jauregui M, Law K, Lippincott-Schwartz J, Brech A, Johansen T, Kim PKJ Cell Sci. 2013 Feb 15;126(Pt 4):939-52. doi: 10.1242/jcs.114819. Epub 2012 Dec 13.3.Molecular determinants of selective clearance of protein inclusions by autophagy.Wong E, Bejarano E, Rakshit M, Lee K, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM.Nat Commun. 2012 Dec 4;3:1240. doi: 10.1038/ncomms2244.4.Nbr1 is a novel inhibitor of ligand-mediated RTK degradation.Mardakheh FK, Auciello G, Dafforn TR, Rappoport JZ, Heath JK.Mol Cell Biol. 2010 Oct 11. [Epub ahead of print]5.Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling.Mardakheh FK, Yekezare M, Machesky LM, Heath JK.J Cell Biol. 2009 Oct 12. [Epub ahead of print]
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