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>   首页   >   产品   >   一抗   >   信号转导   >   NCOA4 Antibody (monoclonal) (M05)   

NCOA4 Antibody (monoclonal) (M05)

Mouse monoclonal antibody raised against a partial recombinant NCOA4.

     
  • 1 - NCOA4 Antibody (monoclonal) (M05) AT2983a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .
  • 1 - NCOA4 Antibody (monoclonal) (M05) AT2983a
    NCOA4 monoclonal antibody (M05), clone 1F11 Western Blot analysis of NCOA4 expression in Hela S3 NE ( (Cat # AT2983a )
  • 2 - NCOA4 Antibody (monoclonal) (M05) AT2983a
    Immunoperoxidase of monoclonal antibody to NCOA4 on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml]
  • 3 - NCOA4 Antibody (monoclonal) (M05) AT2983a
    Immunofluorescence of monoclonal antibody to NCOA4 on HeLa cell. [antibody concentration 10 ug/ml]
  • 10 - NCOA4 Antibody (monoclonal) (M05) AT2983a
    Detection limit for recombinant GST tagged NCOA4 is approximately 0.3ng/ml as a capture antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, IF, E
Primary Accession Q13772
Other Accession NM_005437
Reactivity Human
Host mouse
Clonality monoclonal
Isotype IgG1 Lambda
Clone Names 1F11
Calculated MW 69726 Da
Additional Information
Gene ID 8031
Other Names Nuclear receptor coactivator 4, NCoA-4, Androgen receptor coactivator 70 kDa protein, 70 kDa AR-activator, 70 kDa androgen receptor coactivator, Androgen receptor-associated protein of 70 kDa, Ret-activating protein ELE1, NCOA4, ARA70, ELE1, RFG
Target/Specificity NCOA4 (NP_005428, 505 a.a. ~ 614 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
IHC~~1:100~500
IF~~1:50~200
E~~N/A
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsNCOA4 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.

REFERENCES

Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas. Sadow PM, et al. Endocr Pathol, 2010 Jun. PMID 20012784.The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Landa I, et al. PLoS Genet, 2009 Sep. PMID 19730683.Transcript level modulates the inherent oncogenicity of RET/PTC oncoproteins. Richardson DS, et al. Cancer Res, 2009 Jun 1. PMID 19487296.Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Lu Y, et al. J Lipid Res, 2008 Dec. PMID 18660489.Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70. Peng Y, et al. Am J Pathol, 2008 Jan. PMID 18156210.

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