癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NDRG2 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant NDRG2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q9UN36 |
| Other Accession | NM_016250 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1D12 |
| Calculated MW | 40798 Da |
| Gene ID | 57447 |
|---|---|
| Other Names | Protein NDRG2, N-myc downstream-regulated gene 2 protein, Protein Syld709613, NDRG2, KIAA1248, SYLD |
| Target/Specificity | NDRG2 (NP_057334, 1 a.a. ~ 96 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | NDRG2 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
REFERENCES
NDRG2 is one of novel intrinsic factors for regulation of IL-10 production in human myeloid cell. Choi SC, et al. Biochem Biophys Res Commun, 2010 Jun 4. PMID 20438703.Expression of NDRG2 in esophageal squamous cell carcinoma. Shi H, et al. Cancer Sci, 2010 May. PMID 20331630.HIF-1 and NDRG2 contribute to hypoxia-induced radioresistance of cervical cancer Hela cells. Liu J, et al. Exp Cell Res, 2010 Jul 15. PMID 20206160.NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma. Furuta H, et al. Biochem Biophys Res Commun, 2010 Jan 22. PMID 20045673.NDRG1/2 expression is inhibited in primary acute myeloid leukemia. Tschan MP, et al. Leuk Res, 2010 Mar. PMID 19775754.
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