癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NEDD1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant NEDD1.
- 产品详情
- 实验流程
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q8NHV4 |
| Other Accession | NM_152905 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 7D10 |
| Calculated MW | 71966 Da |
| Gene ID | 121441 |
|---|---|
| Other Names | Protein NEDD1, Neural precursor cell expressed developmentally down-regulated protein 1, NEDD-1, NEDD1 |
| Target/Specificity | NEDD1 (NP_690869, 561 a.a. ~ 660 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | NEDD1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1.The dynamics of microtubule minus ends in the human mitotic spindle.Lecland N, Luders J.Nat Cell Biol. 2014 Jun 29. doi: 10.1038/ncb2996.2.Functional central spindle assembly requires de novo microtubule generation in the interchromosomal region during anaphase.Uehara R, Goshima G.J Cell Biol. 2010 Oct 11. [Epub ahead of print]3.The {gamma}TuRC Revisited: A Comparative Analysis of Interphase and Mitotic Human {gamma}TuRC Redefines the Set of Core Components and Identifies the Novel Subunit GCP8.Teixido-Travesa N, Villen J, Lacasa C, Bertran MT, ArchintiM, Gygi SP, Caelles C, Roig J, Luders J.Originally published as MBoC in Press, 10.1091/mbc.E10-05-04084.SPICE - a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression.Archinti M, Lacasa C, Teixido-Travesa N, Luders J.J Cell Sci. 2010 Sep 15;123(Pt 18):3039-46. Epub 2010 Aug 24.5.Axon Extension Occurs Independently of Centrosomal Microtubule Nucleation.Stiess M, Maghelli N, Kapitein LC, Gomis-Ruth S, Wilsch-Brauninger M, Hoogenraad CC, Tolic-Norrelykke IM, Bradke F.Science. 2010 Feb 5;327(5966):704-7. Epub 2010 Jan 7.6.FAM29A, a target of Plk1 regulation, controls the partitioning of NEDD1 between the mitotic spindle and the centrosomes.Zhu H, Fang K, Fang G.J Cell Sci. 2009 Aug 1;122(Pt 15):2750-9. Epub 2009 Jul 13.7.Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components.Haren L, Stearns T, Luders J.PLoS One. 2009 Jun 19;4(6):e5976.8.FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle.Zhu H, Coppinger JA, Jang CY, Yates JR, III, Fang J.J Cell Biol. 2008 Dec 1;183(5):835-48. Epub 2008 Nov 24.
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