癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NFYC Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant NFYC.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | Q13952 |
| Other Accession | BC005003 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG3 Kappa |
| Clone Names | 1D3 |
| Calculated MW | 50302 Da |
| Gene ID | 4802 |
|---|---|
| Other Names | Nuclear transcription factor Y subunit gamma, CAAT box DNA-binding protein subunit C, Nuclear transcription factor Y subunit C, NF-YC, Transactivator HSM-1/2, NFYC |
| Target/Specificity | NFYC (AAH05003, 14 a.a. ~ 113 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | NFYC Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. Ichikawa S, et al. J Bone Miner Res, 2010 Aug. PMID 20200978.NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor. Murai-Takeda A, et al. J Biol Chem, 2010 Mar 12. PMID 20054001.NF-YC complexity is generated by dual promoters and alternative splicing. Ceribelli M, et al. J Biol Chem, 2009 Dec 4. PMID 19690168.Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple cancers. Yamanaka K, et al. Genomics, 2009 Oct. PMID 19559782.Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Horikawa Y, et al. Clin Cancer Res, 2008 Dec 1. PMID 19047128.
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