癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NGB Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant NGB.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NPG2 |
| Other Accession | BC032509 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 2B5-A7 |
| Calculated MW | 16933 Da |
| Gene ID | 58157 |
|---|---|
| Other Names | Neuroglobin, NGB |
| Target/Specificity | NGB (AAH32509, 1 a.a. ~ 151 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | NGB Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions.
REFERENCES
Neuroglobin genetic polymorphisms and their relationship to functional outcomes after traumatic brain injury. Chuang PY, et al. J Neurotrauma, 2010 Jun. PMID 20345238.Spectroscopic study on acid-induced unfolding and refolding of apo-neuroglobin. Mu J, et al. Spectrochim Acta A Mol Biomol Spectrosc, 2010 May. PMID 20227336.Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death. Raychaudhuri S, et al. Apoptosis, 2010 Apr. PMID 20091232.Neuroglobin expression in ischemic stroke. Jin K, et al. Stroke, 2010 Mar. PMID 20075359.Unusual stability of human neuroglobin at low pH--molecular mechanisms and biological significance. Picotti P, et al. FEBS J, 2009 Dec. PMID 19860834.
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