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>   首页   >   产品   >   一抗   >   心血管   >   NKX2-5 Antibody (monoclonal) (M01)   

NKX2-5 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant NKX2-5.

     
  • 1 - NKX2-5 Antibody (monoclonal) (M01) AT3056a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (61.38 KDa) .
  • 1 - NKX2-5 Antibody (monoclonal) (M01) AT3056a
    NKX2-5 monoclonal antibody (M01), clone 1E4-G5. Western Blot analysis of NKX2-5 expression in human thyroid(diffuse hyperplasia).
  • 1 - NKX2-5 Antibody (monoclonal) (M01) AT3056a
    NKX2-5 monoclonal antibody (M01), clone 1E4-G5 Western Blot analysis of NKX2-5 expression in HeLa ( (Cat # AT3056a )
  • 1 - NKX2-5 Antibody (monoclonal) (M01) AT3056a
    Western Blot analysis of NKX2-5 expression in transfected 293T cell line by NKX2-5 monoclonal antibody (M01), clone 1E4-G5.

    Lane 1: NKX2-5 transfected lysate(34.9 KDa).
    Lane 2: Non-transfected lysate.
  • 10 - NKX2-5 Antibody (monoclonal) (M01) AT3056a
    Detection limit for recombinant GST tagged NKX2-5 is approximately 0.03ng/ml as a capture antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P52952
Other Accession BC025711
Reactivity Human
Host Mouse
Clonality monoclonal
Isotype IgG1 Kappa
Clone Names S3
Calculated MW 34918 Da
Additional Information
Gene ID 1482
Other Names Homeobox protein Nkx-25, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, NKX2-5, CSX, NKX25, NKX2E
Target/Specificity NKX2-5 (AAH25711, 1 a.a. ~ 324 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
E~~N/A
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsNKX2-5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.

REFERENCES

1.Complex SUMO-1 Regulation of Cardiac Transcription Factor Nkx2-5.Costa MW, Lee S, Furtado MB, Xin L, Sparrow DB, Martinez CG, Dunwoodie SL, Kurtenbach E, Mohun T, Rosenthal N, Harvey RP.PLoS One. 2011;6(9):e24812. Epub 2011 Sep 12.2.RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression.Yadava RS, Frenzel-McCardell CD, Yu Q, Srinivasan V, Tucker AL, Puymirat J, Thornton CA, Prall OW, Harvey RP, Mahadevan MS.Nat Genet. 2008 Jan;40(1):61-8. Epub 2007 Dec 16.

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