癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NKX6-1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant NKX6-1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P78426 |
| Other Accession | NM_006168 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1B7 |
| Calculated MW | 37849 Da |
| Gene ID | 4825 |
|---|---|
| Other Names | Homeobox protein Nkx-61, Homeobox protein NK-6 homolog A, NKX6-1, NKX6A |
| Target/Specificity | NKX6-1 (NP_006159, 191 a.a. ~ 275 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | NKX6-1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].
REFERENCES
Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells. Donelan W, et al. J Biol Chem, 2010 Apr 16. PMID 20106981.Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia. Zhu S, et al. Dig Dis Sci, 2009 May. PMID 18754095.Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Schisler JC, et al. Mol Cell Biol, 2008 May. PMID 18347054.Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects. Yokoi N, et al. Diabetes, 2006 Aug. PMID 16873704.Differentiation of insulin-producing cells from human neural progenitor cells. Hori Y, et al. PLoS Med, 2005 Apr. PMID 15839736.
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