癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NOLC1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant NOLC1.
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | Q14978 |
| Other Accession | NM_004741 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG3 Kappa |
| Clone Names | 3F8 |
| Calculated MW | 73603 Da |
| Gene ID | 9221 |
|---|---|
| Other Names | Nucleolar and coiled-body phosphoprotein 1, 140 kDa nucleolar phosphoprotein, Nopp140, Hepatitis C virus NS5A-transactivated protein 13, HCV NS5A-transactivated protein 13, Nucleolar 130 kDa protein, Nucleolar phosphoprotein p130, NOLC1, KIAA0035, NS5ATP13 |
| Target/Specificity | NOLC1 (NP_004732, 590 a.a. ~ 699 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | NOLC1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
NOLC1, an enhancer of nasopharyngeal carcinoma progression, is essential for TP53 to regulate MDM2 expression. Hwang YC, et al. Am J Pathol, 2009 Jul. PMID 19541936.Localization of Nopp140 within mammalian cells during interphase and mitosis. Thiry M, et al. Histochem Cell Biol, 2009 Aug. PMID 19381672.The loss of the snoRNP chaperone Nopp140 from Cajal bodies of patient fibroblasts correlates with the severity of spinal muscular atrophy. Renvois? B, et al. Hum Mol Genet, 2009 Apr 1. PMID 19129172.Characterization of the InsP6-dependent interaction between CK2 and Nopp140. Lee WK, et al. Biochem Biophys Res Commun, 2008 Nov 14. PMID 18790693.Chromatin tethering effects of hNopp140 are involved in the spatial organization of nucleolus and the rRNA gene transcription. Tsai YT, et al. J Biomed Sci, 2008 Jul. PMID 18253863.
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