癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NUDT5 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant NUDT5.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UKK9 |
| Other Accession | NM_014142 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2A3 |
| Calculated MW | 24328 Da |
| Gene ID | 11164 |
|---|---|
| Other Names | ADP-sugar pyrophosphatase, 8-oxo-dGDP phosphatase, Nucleoside diphosphate-linked moiety X motif 5, Nudix motif 5, YSA1H, NUDT5 |
| Target/Specificity | NUDT5 (NP_054861, 120 a.a. ~ 219 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | NUDT5 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999 [PubMed 10373642]).
REFERENCES
Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5. Hori M, et al. Free Radic Biol Med, 2010 May 1. PMID 20144704.NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity. Kamiya H, et al. DNA Repair (Amst), 2009 Oct 2. PMID 19699693.Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies. Zha M, et al. J Mol Biol, 2008 Jun 6. PMID 18462755.A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Rush J, et al. Nat Biotechnol, 2005 Jan. PMID 15592455.
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