癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OCLN Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant OCLN.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, IP, E |
|---|---|
| Primary Accession | Q16625 |
| Other Accession | NM_002538 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1G7 |
| Calculated MW | 59144 Da |
| Gene ID | 100506658 |
|---|---|
| Other Names | Occludin, OCLN |
| Target/Specificity | OCLN (NP_002529, 423 a.a. ~ 522 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | OCLN Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes an integral membrane protein which is located at tight junctions. This protein may be involved in the formation and maintenance of the tight junction. The possibility of several alternatively spliced products has been suggested but the full nature of these products has not been described.
REFERENCES
Nedd4-2 interacts with occludin to inhibit tight junction formation and enhance paracellular conductance in collecting duct epithelia. Raikwar NS, et al. Am J Physiol Renal Physiol, 2010 Aug. PMID 20504882.Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry. Kohaar I, et al. J Virol, 2010 Jul. PMID 20463075.Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Raleigh DR, et al. Mol Biol Cell, 2010 Apr 1. PMID 20164257.The tight junction protein, occludin, regulates the directional migration of epithelial cells. Du D, et al. Dev Cell, 2010 Jan 19. PMID 20152177.Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family. Steed E, et al. BMC Cell Biol, 2009 Dec 22. PMID 20028514.
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