癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ODC1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant ODC1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, IP |
|---|---|
| Primary Accession | P11926 |
| Other Accession | BC025296 |
| Reactivity | Human, Rat |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2G5 |
| Calculated MW | 51148 Da |
| Gene ID | 4953 |
|---|---|
| Other Names | Ornithine decarboxylase, ODC, ODC1 |
| Target/Specificity | ODC1 (AAH25296, 1 a.a. ~ 461 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 IP~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ODC1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.
REFERENCES
Ornithine Decarboxylase-1 Polymorphism, Chemoprevention With Eflornithine and Sulindac, and Outcomes Among Colorectal Adenoma Patients. Zell JA, et al. J Natl Cancer Inst, 2010 Aug 26. PMID 20798393.Ornithine Decarboxylase G316A Genotype and Colorectal Cancer Risk. Hughes D, et al. Colorectal Dis, 2010 Apr 29. PMID 20456464.Ornithine decarboxylase mRNA expression in curatively resected non-small-cell lung cancer. Grimminger PP, et al. Clin Lung Cancer, 2010 Mar 1. PMID 20199977.The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification. Geerts D, et al. Int J Cancer, 2010 May 1. PMID 19960435.Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. Zell JA, et al. Clin Cancer Res, 2009 Oct 1. PMID 19789310.
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