癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OXSR1 Antibody (monoclonal) (M19)
Mouse monoclonal antibody raised against a full length recombinant OXSR1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | O95747 |
| Other Accession | BC008726.1 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1B9 |
| Calculated MW | 58022 Da |
| Gene ID | 9943 |
|---|---|
| Other Names | Serine/threonine-protein kinase OSR1, Oxidative stress-responsive 1 protein, OXSR1 (HGNC:8508) |
| Target/Specificity | OXSR1 (AAH08726.1, 1 a.a. ~ 527 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | OXSR1 Antibody (monoclonal) (M19) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.
REFERENCES
Crystal structure of domain-swapped STE20 OSR1 kinase domain. Lee SJ, et al. Protein Sci, 2009 Feb. PMID 19177573.Structure of the OSR1 kinase, a hypertension drug target. Villa F, et al. Proteins, 2008 Dec. PMID 18831043.Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. Richardson C, et al. J Cell Sci, 2008 Mar 1. PMID 18270262.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Structural insights into the recognition of substrates and activators by the OSR1 kinase. Villa F, et al. EMBO Rep, 2007 Sep. PMID 17721439.
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