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>   首页   >   产品   >   一抗   >   癌症   >   PCDHB10 Antibody (monoclonal) (M07)   

PCDHB10 Antibody (monoclonal) (M07)

Mouse monoclonal antibody raised against a partial recombinant PCDHB10.

     
  • 1 - PCDHB10 Antibody (monoclonal) (M07) AT3222a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
  • 1 - PCDHB10 Antibody (monoclonal) (M07) AT3222a
    PCDHB10 monoclonal antibody (M07), clone 4C4 Western Blot analysis of PCDHB10 expression in NIH/3T3 ( (Cat # AT3222a )
  • 3 - PCDHB10 Antibody (monoclonal) (M07) AT3222a
    Immunofluorescence of monoclonal antibody to PCDHB10 on HeLa cell. [antibody concentration 10 ug/ml]
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF
Primary Accession Q9UN67
Other Accession NM_018930
Reactivity Human, Mouse
Host mouse
Clonality monoclonal
Isotype IgG2a Kappa
Clone Names 4C4
Calculated MW 87621 Da
Additional Information
Gene ID 56126
Other Names Protocadherin beta-10, PCDH-beta-10, PCDHB10
Target/Specificity PCDHB10 (NP_061753, 27 a.a. ~ 125 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
IF~~1:50~200
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsPCDHB10 Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

REFERENCES

1.Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer.Balagurunathan Y, Morse DL, Hostetter G, Shanmugam V, Stafford P, Shack S, Pearson J, Trissal M, Demeure MJ, Von Hoff DD, Hruby VJ, Gillies RJ, Han H.Mol Cancer Ther. 2008 Sep;7(9):3071-80. Epub 2008 Sep 2.

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