癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PGEA1 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant CBY1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y3M2 |
| Other Accession | NM_015373 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2F2 |
| Calculated MW | 14470 Da |
| Gene ID | 25776 |
|---|---|
| Other Names | Protein chibby homolog 1, ARPP-binding protein, Cytosolic leucine-rich protein, PIGEA-14, PKD2 interactor, Golgi and endoplasmic reticulum-associated 1, CBY1, ARB1, C22orf2, CBY, PGEA1 |
| Target/Specificity | CBY1 (NP_056188, 18 a.a. ~ 126 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PGEA1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma. Vandepoele K, et al. Exp Cell Res, 2010 Apr 15. PMID 20096688.Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling. Li FQ, et al. Mol Biol Cell, 2010 Jan 15. PMID 19940019.Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. Menon R, et al. Reprod Biol Endocrinol, 2009 Jun 15. PMID 19527514.Chibby forms a homodimer through a heptad repeat of leucine residues in its C-terminal coiled-coil motif. Mofunanya A, et al. BMC Mol Biol, 2009 May 12. PMID 19435523.Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. Velez DR, et al. Am J Obstet Gynecol, 2009 Feb. PMID 19019335.
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