癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PGR Antibody (monoclonal) (M07)
Mouse monoclonal antibody raised against a partial recombinant PGR. This PGR gene uses two distinct
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- 背景知识
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | P06401 |
| Other Accession | NM_000926 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 5D10 |
| Calculated MW | 98981 Da |
| Gene ID | 5241 |
|---|---|
| Other Names | Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3 |
| Target/Specificity | PGR (NP_000917, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PGR Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.
REFERENCES
1.Major Functional Transcriptome of an Inferred Center Regulator of an ER(-) Breast Cancer Model System.Liu LY, Chang LY, Kuo WH, Hwa HL, Lin YS, Huang SF, Chen CN, Chang KJ, Hsieh FJ.Cancer Inform. 2012;11:87-111. Epub 2012 Apr 19.2.In Silico Prediction for Regulation of Transcription Factors onTheir Shared Target Genes Indicates Relevant Clinical Implications in a Breast Cancer Population.Liu LY, Chang LY, Kuo WH, Hwa HL, Shyu MK, Chang KJ, Hsieh FJ.Cancer Inform. 2012;11:113-37. Epub 2012 Apr 19.
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