癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PLK1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant PLK1.
- 产品详情
- 实验流程
Application 
| WB, IF, IP, E |
|---|---|
| Primary Accession | P53350 |
| Other Accession | BC002369 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 2G12 |
| Calculated MW | 68255 Da |
| Gene ID | 5347 |
|---|---|
| Other Names | Serine/threonine-protein kinase PLK1, Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13, PLK1, PLK |
| Target/Specificity | PLK1 (AAH02369, 1 a.a. ~ 603 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PLK1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A. Chen YC, et al. J Virol, 2010 Aug. PMID 20534861.Centrobin/NIP2 is a microtubule stabilizer whose activity is enhanced by PLK1 phosphorylation during mitosis. Lee J, et al. J Biol Chem, 2010 Aug 13. PMID 20511645.Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2010 May 28. PMID 20508983.Liaisons between survivin and Plk1 during cell division and cell death. Colnaghi R, et al. J Biol Chem, 2010 Jul 16. PMID 20427271.A functional link between polo-like kinase 1 and the mammalian target-of-rapamycin pathway? Renner AG, et al. Cell Cycle, 2010 May. PMID 20404504.
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