癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
POLS Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant POLS.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q5XG87 |
| Other Accession | NM_006999 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2F8 |
| Calculated MW | 84650 Da |
| Gene ID | 11044 |
|---|---|
| Other Names | Non-canonical poly(A) RNA polymerase PAPD7, DNA polymerase sigma, LAK-1, PAP-associated domain-containing protein 7, TRAMP-like complex polyadenylate polymerase, Terminal uridylyltransferase 5, TUTase 5, Topoisomerase-related function protein 4-1, TRF4-1, PAPD7, POLS, TRF4 |
| Target/Specificity | POLS (NP_008930, 2 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | POLS Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described.
REFERENCES
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Need AC, et al. Hum Mol Genet, 2009 Dec 1. PMID 19734545.Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061.Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder. Mick E, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Dec 5. PMID 18821564.A genome-wide scan maps a novel high myopia locus to 5p15. Lam CY, et al. Invest Ophthalmol Vis Sci, 2008 Sep. PMID 18421076.Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine. Jarjanazi H, et al. Hum Mutat, 2008 Apr. PMID 18330920.
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