癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
POMGNT1 Antibody (monoclonal) (M07)
Mouse monoclonal antibody raised against a partial recombinant POMGNT1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q8WZA1 |
| Other Accession | NM_017739 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 6C12 |
| Calculated MW | 75252 Da |
| Gene ID | 55624 |
|---|---|
| Other Names | Protein O-linked-mannose beta-1, 2-N-acetylglucosaminyltransferase 1, POMGnT1, 241-, UDP-GlcNAc:alpha-D-mannoside beta-1, 2-N-acetylglucosaminyltransferase I2, GnT I2, POMGNT1, MGAT12 |
| Target/Specificity | POMGNT1 (NP_060209, 221 a.a. ~ 318 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | POMGNT1 Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a type II transmembrane protein that resides in the golgi. It participates in O-mannosyl glycosylation, and is specific for alpha linked terminal mannose. Mutations in this gene are associated with muscle-eye-brain (MEB) disease. Alternatively spliced transcript variants have been found for this gene.
REFERENCES
Congenital muscular dystrophies with defective glycosylation of dystroglycan: a population study. Mercuri E, et al. Neurology, 2009 May 26. PMID 19299310.Novel POMGnT1 mutations define broader phenotypic spectrum of muscle-eye-brain disease. Hehr U, et al. Neurogenetics, 2007 Nov. PMID 17906881.Severe muscle-eye-brain disease is associated with a homozygous mutation in the POMGnT1 gene. Teber S, et al. Eur J Paediatr Neurol, 2008 Mar. PMID 17881266.Refining genotype phenotype correlations in muscular dystrophies with defective glycosylation of dystroglycan. Godfrey C, et al. Brain, 2007 Oct. PMID 17878207.Protein O-mannosyltransferase activities in lymphoblasts from patients with alpha-dystroglycanopathies. Manya H, et al. Neuromuscul Disord, 2008 Jan. PMID 17869517.
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