癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PRPF19 Antibody (monoclonal) (M07)
Mouse monoclonal antibody raised against a partial recombinant PRPF19.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q9UMS4 |
| Other Accession | NM_014502 |
| Reactivity | Human, Mouse, Rat |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2E6 |
| Calculated MW | 55181 Da |
| Gene ID | 27339 |
|---|---|
| Other Names | Pre-mRNA-processing factor 19, 632-, Nuclear matrix protein 200, PRP19/PSO4 homolog, hPso4, Senescence evasion factor, PRPF19 (HGNC:17896) |
| Target/Specificity | PRPF19 (NP_055317, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PRPF19 Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).
REFERENCES
Regulation of Metnase's TIR binding activity by its binding partner, Pso4. Beck BD, et al. Arch Biochem Biophys, 2010 Jun 15. PMID 20416268.Molecular architecture of the human Prp19/CDC5L complex. Grote M, et al. Mol Cell Biol, 2010 May. PMID 20176811.Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4. Grillari J, et al. J Biol Chem, 2009 Oct 16. PMID 19641227.Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair. Beck BD, et al. J Biol Chem, 2008 Apr 4. PMID 18263876.Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
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