癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PTF1A Antibody (monoclonal) (M09)
Mouse monoclonal antibody raised against a partial recombinant PTF1A.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q7RTS3 |
| Other Accession | NM_178161 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Lambda |
| Clone Names | 1H1 |
| Calculated MW | 34970 Da |
| Gene ID | 256297 |
|---|---|
| Other Names | Pancreas transcription factor 1 subunit alpha, Class A basic helix-loop-helix protein 29, bHLHa29, Pancreas-specific transcription factor 1a, bHLH transcription factor p48, p48 DNA-binding subunit of transcription factor PTF1, PTF1-p48, PTF1A, BHLHA29, PTF1P48 |
| Target/Specificity | PTF1A (NP_835455, 250 a.a. ~ 328 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PTF1A Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.
REFERENCES
Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex. Meredith DM, et al. J Neurosci, 2009 Sep 9. PMID 19741120.A Turkish newborn infant with cerebellar agenesis/neonatal diabetes mellitus and PTF1A mutation. Tutak E, et al. Genet Couns, 2009. PMID 19650412.p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation. Rodolosse A, et al. Biochem J, 2009 Mar 1. PMID 18834332.Origin of climbing fiber neurons and their developmental dependence on Ptf1a. Yamada M, et al. J Neurosci, 2007 Oct 10. PMID 17928434.PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L. Beres TM, et al. Mol Cell Biol, 2006 Jan. PMID 16354684.
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