癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PTN Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PTN.
- 产品详情
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | P21246 |
| Other Accession | NM_002825 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 5C3 |
| Calculated MW | 18942 Da |
| Gene ID | 5764 |
|---|---|
| Other Names | Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule, HB-GAM, Heparin-binding neurite outgrowth-promoting factor 1, HBNF-1, Osteoblast-specific factor 1, OSF-1, PTN, HBNF1, NEGF1 |
| Target/Specificity | PTN (NP_002816, 45 a.a. ~ 154 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PTN Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1.Expression of the growth factor pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in the serum, cartilage and subchondral bone of patients with osteoarthritis.Kaspiris A, Mikelis C, Heroult M, Khaldi L, Grivas TB, Kouvaras I, Dangas S, Vasiliadis E, Liote F, Courty J, Papadimitriou E.Joint Bone Spine. 2013 Jan 17. doi:pii: S1297-319X(12)00296-5. 10.1016/j.jbspin.2012.10.024. [Epub ahead of print]2.Interplay between ?v?]3 Integrin and Nucleolin Regulates Human Endothelial and Glioma Cell Migration.Koutsioumpa M, Polytarchou C, Courty J, Zhang Y, Kieffer N, Mikelis C, Skandalis SS, Hellman U, Iliopoulos D, Papadimitriou E.J Biol Chem. 2013 Jan 4;288(1):343-54. doi: 10.1074/jbc.M112.387076. Epub 2012 Nov 16.3.Pleiotrophin promotes microglia proliferation and secretion of neurotrophic factors by activating extracellular signal-regulated kinase 1/2 pathway.Miao J, Ding M, Zhang A, Xiao Z, Qi W, Luo N, Di W, Tao Y, Fang Y.Neurosci Res. 2012 Sep 18. pii: S0168-0102(12)00173-3. doi: 10.1016/j.neures.2012.09.001. [Epub ahead of print]4.Implications of pleiotrophin in human PC3 prostate cancer cell growth in vivo.Tsirmoula S, Dimas K, Hatziapostolou M, Lamprou M, Ravazoula P, Papadimitriou E.Cancer Sci. 2012 Oct;103(10):1826-32. doi: 10.1111/j.1349-7006.2012.02383.x. Epub 2012 Aug 14.5.A peptide corresponding to the C-terminal region of pleiotrophin inhibits angiogenesis in vivo and in vitro.Mikelis C, Lamprou M, Koutsioumpa M, Koutsioubas AG, Spyranti Z, Zompra AA, Spiliopoulos N, Vradis AA, Katsoris P, Spyroulias GA, Cordopatis P, Courty J, Papadimitriou E.J Cell Biochem. 2011 Feb 22. doi: 10.1002/jcb.23066. [Epub ahead of print]6.Integrin {alpha}{nu}{beta}3 is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase {beta}/{zeta}.Mikelis C, Sfaelou E, Koutsioumpa M, Kieffer N, Papadimitriou E.FASEB J. 2009 May;23(5):1459-69. Epub 2009 Jan 13.7.Aprotinin stimulates angiogenesis and human endothelial cell migration through the growth factor pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta.Koutsioumpa M, Hatziapostolou M, Mikelis C, Koolwijk P, Papadimitriou E.Eur J Pharmacol. 2009 Jan 14;602(2-3):245-9. Epub 2008 Dec 3.
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