癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RAP1GA1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant RAP1GA1.
- 产品详情
- 实验流程
Application 
| E |
|---|---|
| Primary Accession | P47736 |
| Other Accession | BC054490 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 3G11 |
| Calculated MW | 73361 Da |
| Gene ID | 5909 |
|---|---|
| Other Names | Rap1 GTPase-activating protein 1, Rap1GAP, Rap1GAP1, RAP1GAP, KIAA0474, RAP1GA1 |
| Target/Specificity | RAP1GA1 (AAH54490.1, 1 a.a. ~ 663 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | RAP1GA1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion. Tsygankova OM, et al. Mol Cell Biol, 2010 Jul. PMID 20439492.Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors. Zuo H, et al. Cancer Res, 2010 Feb 15. PMID 20124489.The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb. Kupzig S, et al. Mol Cell Biol, 2009 Jul. PMID 19433443.Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. Zheng H, et al. Cancer Res, 2009 Jan 15. PMID 19147557.Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. Enjuanes A, et al. Cancer Res, 2008 Dec 15. PMID 19074885.
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