癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RCHY1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant RCHY1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q96PM5 |
| Other Accession | NM_015436 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 5D12 |
| Calculated MW | 30110 Da |
| Gene ID | 25898 |
|---|---|
| Other Names | RING finger and CHY zinc finger domain-containing protein 1, 632-, Androgen receptor N-terminal-interacting protein, CH-rich-interacting match with PLAG1, E3 ubiquitin-protein ligase Pirh2, RING finger protein 199, Zinc finger protein 363, p53-induced RING-H2 protein, hPirh2, RCHY1, ARNIP, CHIMP, PIRH2, RNF199, ZNF363 |
| Target/Specificity | RCHY1 (NP_056251, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | RCHY1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.
REFERENCES
A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination. Yan J, et al. FEBS Lett, 2010 Aug 4. PMID 20598683.A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma. Wu G, et al. FEBS Lett, 2010 Jul 2. PMID 20452352.Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation. Jung YS, et al. Mol Cell Biol, 2010 Feb. PMID 20008555.Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2. Min SH, et al. Life Sci, 2010 Jan 2. PMID 19945467.Measles virus: evidence for association with lung cancer. Sion-Vardy N, et al. Exp Lung Res, 2009 Oct. PMID 19895323.
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