癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
REPS2 Antibody (monoclonal) (M01A)
Mouse monoclonal antibody raised against a partial recombinant REPS2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q8NFH8 |
| Other Accession | NM_004726 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgM Kappa |
| Clone Names | 4C2 |
| Calculated MW | 71534 Da |
| Gene ID | 9185 |
|---|---|
| Other Names | RalBP1-associated Eps domain-containing protein 2, Partner of RalBP1, RalBP1-interacting protein 2, REPS2, POB1 |
| Target/Specificity | REPS2 (NP_004717, 66 a.a. ~ 165 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | REPS2 Antibody (monoclonal) (M01A) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
TMEM25, REPS2 and Meis 1: favourable prognostic and predictive biomarkers for breast cancer. Doolan P, et al. Tumour Biol, 2009. PMID 19776672.Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1. Singhal SS, et al. J Biol Chem, 2008 Jul 11. PMID 18474607.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. Yadav S, et al. Biochem Biophys Res Commun, 2005 Mar 25. PMID 15707977.EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2. Oosterhoff JK, et al. Int J Cancer, 2005 Feb 10. PMID 15455380.
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