癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RHOH Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a full length recombinant RHOH.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | Q15669 |
| Other Accession | BC014261 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3D3 |
| Calculated MW | 21331 Da |
| Gene ID | 399 |
|---|---|
| Other Names | Rho-related GTP-binding protein RhoH, GTP-binding protein TTF, Translocation three four protein, RHOH, ARHH, TTF |
| Target/Specificity | RHOH (AAH14261.1, 1 a.a. ~ 191 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | RHOH Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the Ras superfamily of small GTPases. Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. This gene encodes a small G-like protein, and unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Lysosomal degradation of RhoH protein upon antigen receptor activation in T but not B cells. Schmidt-Mende J, et al. Eur J Immunol, 2010 Feb. PMID 19950172.Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia. Sanchez-Aguilera A, et al. Leukemia, 2010 Jan. PMID 19847197.RhoH/TTF negatively regulates leukotriene production in neutrophils. Daryadel A, et al. J Immunol, 2009 May 15. PMID 19414807.Prognostic implication and biological roles of RhoH in acute myeloid leukaemia. Iwasaki T, et al. Eur J Haematol, 2008 Dec. PMID 18691253.
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