癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RNASEL Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant RNASEL.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | Q05823 |
| Other Accession | NM_021133 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 3B4 |
| Calculated MW | 83533 Da |
| Gene ID | 6041 |
|---|---|
| Other Names | 2-5A-dependent ribonuclease, 2-5A-dependent RNase, 3126-, Ribonuclease 4, Ribonuclease L, RNase L, RNASEL, RNS4 |
| Target/Specificity | RNASEL (NP_066956, 619 a.a. ~ 728 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | RNASEL Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.
REFERENCES
Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Silva LK, et al. Eur J Hum Genet, 2010 Jun 30. PMID 20588308.Genetic variation in RNASEL associated with prostate cancer risk and progression. Meyer MS, et al. Carcinogenesis, 2010 Sep. PMID 20576793.Contribution of HPC1 (RNASEL) and HPCX variants to prostate cancer in a founder population. Agalliu I, et al. Prostate, 2010 Jun 16. PMID 20564318.Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells. Bhosle S, et al. J Virol, 2010 Jul. PMID 20410264.Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. Mosbruger TL, et al. J Infect Dis, 2010 May 1. PMID 20331378.
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