癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RNUT1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant RNUT1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF |
|---|---|
| Primary Accession | O95149 |
| Other Accession | BC004203 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a kappa |
| Clone Names | 2B2-1B4 |
| Calculated MW | 41143 Da |
| Gene ID | 10073 |
|---|---|
| Other Names | Snurportin-1, RNA U transporter 1, SNUPN, RNUT1, SPN1 |
| Target/Specificity | RNUT1 (AAH04203, 1 a.a. ~ 360 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | RNUT1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
REFERENCES
Molecular determinants of snurportin 1 ligand affinity and structural response upon binding. Goette M, et al. Biophys J, 2009 Jul 22. PMID 19619473.Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP. Monecke T, et al. Science, 2009 May 22. PMID 19389996.A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.Cross-talk between snurportin1 subdomains. Ospina JK, et al. Mol Biol Cell, 2005 Oct. PMID 16030253.Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1. Strasser A, et al. EMBO J, 2005 Jul 6. PMID 15920472.
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