癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RTN2 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant RTN2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O75298 |
| Other Accession | NM_005619 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 6A11 |
| Calculated MW | 59264 Da |
| Gene ID | 6253 |
|---|---|
| Other Names | Reticulon-2, Neuroendocrine-specific protein-like 1, NSP-like protein 1, Neuroendocrine-specific protein-like I, NSP-like protein I, NSPLI, RTN2, NSPL1 |
| Target/Specificity | RTN2 (NP_005610, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | RTN2 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
REFERENCES
Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4. Ikemoto T, et al. Diabetes, 2009 Dec. PMID 19720795.Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1. Liu Y, et al. J Biol Chem, 2008 Mar 7. PMID 18096700.Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747.Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. He W, et al. Nat Med, 2004 Sep. PMID 15286784.Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. Reuter TY, et al. Exp Cell Res, 2003 Oct 1. PMID 14499622.
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