癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
S100A13 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant S100A13.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q99584 |
| Other Accession | NM_005979 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3A7 |
| Calculated MW | 11471 Da |
| Gene ID | 6284 |
|---|---|
| Other Names | Protein S100-A13, S100 calcium-binding protein A13, S100A13 |
| Target/Specificity | S100A13 (NP_005970, 1 a.a. ~ 98 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | S100A13 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
REFERENCES
S100A13 is a new angiogenic marker in human melanoma. Massi D, et al. Mod Pathol, 2010 Jun. PMID 20208480.S100A13-C2A binary complex structure-a key component in the acidic fibroblast growth factor for the non-classical pathway. Mohan SK, et al. Biochem Biophys Res Commun, 2009 Mar 13. PMID 19284995.Structure of calcium-bound human S100A13 at pH 7.5 at 1.8 A resolution. Imai FL, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Feb 1. PMID 18259052.Crystal structure study on human S100A13 at 2.0 A resolution. Li M, et al. Biochem Biophys Res Commun, 2007 May 11. PMID 17374362.Crystallization and preliminary X-ray analysis of human S100A13. Imai FL, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Nov 1. PMID 17077500.
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