S100A4 Antibody (monoclonal) (M01)

Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

REFERENCES

1.Cancer-Initiating Cells from Colorectal Cancer Patients Escape from T Cell-Mediated Immunosurveillance In Vitro through Membrane-Bound IL-4.Volonte A, Di Tomaso T, Spinelli M, Todaro M, Sanvito F, Albarello L, Bissolati M, Ghirardelli L, Orsenigo E, Ferrone S, Doglioni C, Stassi G, Dellabona P, Staudacher C, Parmiani G, Maccalli CJ Immunol. 2013 Nov 25.2.Identification of novel molecular markers through transcriptomic analysis in human fetal and adult corneal endothelial cells.Chen Y, Huang K, Nakatsu MN, Xue Z, Deng SX, Fan G.Hum Mol Genet. 2013 Jan 8.3.MiR-21/Smad 7 signaling determines TGF-?1-induced CAF formation.Li Q, Zhang D, Wang Y, Sun P, Hou X, Larner J, Xiong W, Mi JSci Rep. 2013;3:2038. doi: 10.1038/srep02038.4.Androgen receptor expression in satellite cells of the neonatal levator ani of the rat.Swift-Gallant A, Monks DA.Dev Neurobiol. 2012 Dec 12. doi: 10.1002/dneu.22066.5.Potential role for S100A4 in the disruption of the blood-brain barrier in collagen-induced arthritic mice, an animal model of rheumatoid arthritis.Nishioku T, Furusho K, Tomita A, Ohishi H, Dohgu S, Shuto H, Yamauchi A, Kataoka Y.Neuroscience. 2011 May 26. [Epub ahead of print]