癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SEC24D Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant SEC24D.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O94855 |
| Other Accession | NM_014822 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1A8 |
| Calculated MW | 113010 Da |
| Gene ID | 9871 |
|---|---|
| Other Names | Protein transport protein Sec24D, SEC24-related protein D, SEC24D, KIAA0755 |
| Target/Specificity | SEC24D (NP_055637, 935 a.a. ~ 1032 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SEC24D Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. This gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration.
REFERENCES
1.Hsp70 Promotes Epithelial Sodium Channel Functional Expression by Increasing Its Association with Coat Complex II and Its Exit from Endoplasmic Reticulum.Chanoux RA, Robay A, Shubin CB, Kebler C, Suaud L, Rubenstein RC.J Biol Chem. 2012 Jun 1;287(23):19255-65. Epub 2012 Apr 10.2.Role of Rab1b in COPII dynamics and function.Slavin I, Garcia IA, Monetta P, Martinez H, Romero N, Alvarez C.Eur J Cell Biol. 2010 Nov 17. [Epub ahead of print]3.New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites.Lee I, Ajay SS, Yook JI, Kim HS, Hong SH, Kim NH, Dhanasekaran SM, Chinnaiyan AM, Athey BD.Genome Res. 2009 Jul;19(7):1175-83. Epub 2009 Mar 31.
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