癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SGCA Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SGCA.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q16586 |
| Other Accession | NM_000023 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 3C4 |
| Calculated MW | 42875 Da |
| Gene ID | 6442 |
|---|---|
| Other Names | Alpha-sarcoglycan, Alpha-SG, 50 kDa dystrophin-associated glycoprotein, 50DAG, Adhalin, Dystroglycan-2, SGCA, ADL, DAG2 |
| Target/Specificity | SGCA (NP_000014.1, 26 a.a. ~ 133 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SGCA Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts. Fernandez K, et al. Am J Pathol, 2010 Jan. PMID 20019182.Sarcoglycanopathies: can muscle immunoanalysis predict the genotype? Klinge L, et al. Neuromuscul Disord, 2008 Dec. PMID 18996010.Identification of two E-boxes that negatively modulate the activity of MyoD on the alpha-sarcoglycan core promoter. Delgado-Olgu?n P, et al. Biochim Biophys Acta, 2008 Jan. PMID 18078839.Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development. Rafii MS, et al. J Cell Physiol, 2006 Nov. PMID 16883602.Sarcoglycanopathies and the risk of undetected deletion alleles in diagnosis. White SJ, et al. Hum Mutat, 2005 Jul. PMID 15954112.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
