癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SH3GLB1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SH3GLB1.
- 产品详情
- 实验流程
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q9Y371 |
| Other Accession | BC007455 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1B3-A5 |
| Calculated MW | 40796 Da |
| Gene ID | 51100 |
|---|---|
| Other Names | Endophilin-B1, Bax-interacting factor 1, Bif-1, SH3 domain-containing GRB2-like protein B1, SH3GLB1, KIAA0491 |
| Target/Specificity | SH3GLB1 (AAH07455, 1 a.a. ~ 365 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SH3GLB1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death. Yang J, et al. J Cell Sci, 2010 Mar 15. PMID 20159967.Bax activates endophilin B1 oligomerization and lipid membrane vesiculation. Rostovtseva TK, et al. J Biol Chem, 2009 Dec 4. PMID 19805544.Somatic mutation of pro-cell death Bif-1 gene is rare in common human cancers. Kim MS, et al. APMIS, 2008 Oct. PMID 19132989.Bif-1 and Bax expression in cutaneous Merkel cell carcinoma. Schlauder SM, et al. J Cutan Pathol, 2009 Jan. PMID 19125733.Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements. Etxebarria A, et al. J Biol Chem, 2009 Feb 13. PMID 19074440.
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