癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SIGIRR Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SIGIRR.
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q6IA17 |
| Other Accession | BC003591 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgM kappa |
| Clone Names | 3H8-2G3 |
| Calculated MW | 45679 Da |
| Gene ID | 59307 |
|---|---|
| Other Names | Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, TIR8, SIGIRR |
| Target/Specificity | SIGIRR (AAH03591, 1 a.a. ~ 410 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SIGIRR Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis. Drexler SK, et al. Arthritis Rheum, 2010 Aug. PMID 20506350.Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. Mosbruger TL, et al. J Infect Dis, 2010 May 1. PMID 20331378.The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells. Khan MA, et al. J Immunol, 2010 Mar 1. PMID 20130217.TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization. Garlanda C, et al. Trends Immunol, 2009 Sep. PMID 19699681.Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. Verstraelen H, et al. J Reprod Immunol, 2009 Jan. PMID 19200604.
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