癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC26A4 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant SLC26A4.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | O43511 |
| Other Accession | NM_000441 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3D2 |
| Calculated MW | 85723 Da |
| Gene ID | 5172 |
|---|---|
| Other Names | Pendrin, Sodium-independent chloride/iodide transporter, Solute carrier family 26 member 4, SLC26A4, PDS |
| Target/Specificity | SLC26A4 (NP_000432, 674 a.a. ~ 754 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SLC26A4 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters.
REFERENCES
Genetic causes of nonsyndromic hearing loss in Iran in comparison with other populations. Mahdieh N, et al. J Hum Genet, 2010 Aug 26. PMID 20739942.Genotyping with a 198 mutation arrayed primer extension array for hereditary hearing loss: assessment of its diagnostic value for medical practice. Rodriguez-Paris J, et al. PLoS One, 2010 Jul 26. PMID 20668687.Screening of SLC26A4, FOXI1 and KCNJ10 genes in unilateral hearing impairment with ipsilateral enlarged vestibular aqueduct. Jonard L, et al. Int J Pediatr Otorhinolaryngol, 2010 Sep. PMID 20621367.Spectrum and frequency of SLC26A4 mutations among Czech patients with early hearing loss with and without Enlarged Vestibular Aqueduct (EVA). Pourov? R, et al. Ann Hum Genet, 2010 Jul. PMID 20597900.Causes of hearing impairment in the Norwegian paediatric cochlear implant program. Siem G, et al. Int J Audiol, 2010 Aug. PMID 20553101.
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