癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC27A4 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SLC27A4.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6P1M0 |
| Other Accession | BC009959 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1F4-1B10 |
| Calculated MW | 72064 Da |
| Gene ID | 10999 |
|---|---|
| Other Names | Long-chain fatty acid transport protein 4, FATP-4, Fatty acid transport protein 4, 621-, Solute carrier family 27 member 4, SLC27A4, ACSVL4, FATP4 |
| Target/Specificity | SLC27A4 (AAH09959.1, 1 a.a. ~ 237 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SLC27A4 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome.
REFERENCES
1.Interactions between FATP4 and ichthyin in epidermal lipid processing may provide clues to the pathogenesis of autosomal recessive congenital ichthyosis.Li H, Vahlquist A, Torma H.J Dermatol Sci. 2012 Dec 13. pii: S0923-1811(12)00938-3. doi: 10.1016/j.jdermsci.2012.11.593.2.Adipokines promote lipotoxicity in human skeletal muscle cells.Taube A, Lambernd S, van Echten-Deckert G, Eckardt K, Eckel J.Arch Physiol Biochem. 2012 Jul;118(3):92-101. Epub 2012 Jun 12.3.Modulation of Fatty Acid Transport and Metabolism by Obesity in the Human Full-Term Placenta.Dube E, Gravel A, Martin C, Desparois G, Moussa I, Ethier-Chiasson M, Forest JC, Giguere Y, Masse A, Lafond J.Biol Reprod. 2012 May 2.4.Mutations in the Fatty Acid Transport Protein 4 Gene Cause the Ichthyosis Prematurity Syndrome.Klar J, Schweiger M, Zimmerman R, Zechner R, Li H, Torma H, Vahlquist A, Bouadjar B, Dahl N, Fischer J.Am J Hum Genet. 2009 Aug;85(2):248-53. Epub 2009 Jul 23.5.Fatty acid transport and activation and the expression patterns of genes involved in fatty acid trafficking.Sandoval A, Fraisl P, Arias-Barrau E, DiRusso CD, Singer D, Sealls W, Black PN.Arch Biochem Biophys. 2008 Sep 15;477(2):363-71. Epub 2008 Jun 20.
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