癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SMAD7 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant SMAD7.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O15105 |
| Other Accession | NM_005904 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2G6 |
| Calculated MW | 46426 Da |
| Gene ID | 4092 |
|---|---|
| Other Names | Mothers against decapentaplegic homolog 7, MAD homolog 7, Mothers against DPP homolog 7, Mothers against decapentaplegic homolog 8, MAD homolog 8, Mothers against DPP homolog 8, SMAD family member 7, SMAD 7, Smad7, hSMAD7, SMAD7, MADH7, MADH8 |
| Target/Specificity | SMAD7 (NP_005895, 160 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SMAD7 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs European Descent. Kupfer SS, et al. Gastroenterology, 2010 Jul 24. PMID 20659471. Association studies on 11 published colorectal cancer risk loci. von Holst S, et al. Br J Cancer, 2010 Aug 10. PMID 20648012. Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype. Abul? A, et al. Gastroenterology, 2010 Sep. PMID 20638935. Hypoxic conversion of SMAD7 function from an inhibitor into a promoter of cell invasion. Heikkinen PT, et al. Cancer Res, 2010 Jul 15. PMID 20551054. Risk of genome-wide association study-identified genetic variants for colorectal cancer in a Chinese population. Xiong F, et al. Cancer Epidemiol Biomarkers Prev, 2010 Jul. PMID 20530476.
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