癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SMARCD3 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant SMARCD3.
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6STE5 |
| Other Accession | NM_001003801 |
| Reactivity | Human, Mouse, Rat |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5B6 |
| Calculated MW | 55016 Da |
| Gene ID | 6604 |
|---|---|
| Other Names | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3, 60 kDa BRG-1/Brm-associated factor subunit C, BRG1-associated factor 60C, BAF60C, SMARCD3, BAF60C |
| Target/Specificity | SMARCD3 (NP_001003801, 385 a.a. ~ 483 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SMARCD3 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
REFERENCES
Baf60c is a component of the neural progenitor-specific BAF complex in developing retina. Lamba DA, et al. Dev Dyn, 2008 Oct. PMID 18816825.Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. Mahmoudi T, et al. J Biol Chem, 2006 Jul 21. PMID 16687403.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. Debril MB, et al. J Biol Chem, 2004 Apr 16. PMID 14701856.
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