癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SPAG5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SPAG5.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q96R06 |
| Other Accession | BC000322 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG3 Kappa |
| Clone Names | 5F9 |
| Calculated MW | 134422 Da |
| Gene ID | 10615 |
|---|---|
| Other Names | Sperm-associated antigen 5, Astrin, Deepest, Mitotic spindle-associated protein p126, MAP126, SPAG5 |
| Target/Specificity | SPAG5 (AAH00322, 1082 a.a. ~ 1191 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SPAG5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.
REFERENCES
Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2010 May 28. PMID 20508983.SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint. Liu L, et al. Cell Cycle, 2009 Feb 15. PMID 19197158.Astrin regulates Aurora-A localization. Du J, et al. Biochem Biophys Res Commun, 2008 May 30. PMID 18361916.Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin. Cheng TS, et al. J Biol Chem, 2008 Jan 25. PMID 18055457.Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity. Thein KH, et al. J Cell Biol, 2007 Jul 30. PMID 17664331.
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