癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SPDEF Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SPDEF.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O95238 |
| Other Accession | NM_012391 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 4A5 |
| Calculated MW | 37518 Da |
| Gene ID | 25803 |
|---|---|
| Other Names | SAM pointed domain-containing Ets transcription factor, Prostate epithelium-specific Ets transcription factor, Prostate-specific Ets, Prostate-derived Ets factor, SPDEF, PDEF, PSE |
| Target/Specificity | SPDEF (NP_036523, 92 a.a. ~ 200 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SPDEF Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.
REFERENCES
Transcriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progression. Schaefer JS, et al. J Biol Chem, 2010 Apr 9. PMID 20139077.PDEF is a negative regulator of colon cancer cell growth and migration. Moussa O, et al. J Cell Biochem, 2009 Dec 15. PMID 19830706.SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells. Noah TK, et al. Exp Cell Res, 2010 Feb 1. PMID 19786015.Sam-pointed domain containing Ets transcription factor in luminal breast cancer pathogenesis. Sood AK, et al. Cancer Epidemiol Biomarkers Prev, 2009 Jun. PMID 19505923.Proteomic analysis of a PDEF Ets transcription factor-interacting protein complex. Cho JY, et al. J Proteome Res, 2009 Mar. PMID 19203193.
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