癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SPINK1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SPINK1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IP, E |
|---|---|
| Primary Accession | P00995 |
| Other Accession | BC025790 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4D4 |
| Calculated MW | 8507 Da |
| Gene ID | 6690 |
|---|---|
| Other Names | Pancreatic secretory trypsin inhibitor, Serine protease inhibitor Kazal-type 1, Tumor-associated trypsin inhibitor, TATI, SPINK1, PSTI |
| Target/Specificity | SPINK1 (AAH25790, 24 a.a. ~ 79 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SPINK1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.
REFERENCES
1.HOXB13 G84E-related Familial Prostate Cancers: A Clinical, Histologic, and Molecular Survey.Smith SC, Palanisamy N, Zuhlke KA, Johnson AM, Siddiqui J, Chinnaiyan AM, Kunju LP, Cooney KA, Tomlins SAAm J Surg Pathol. 2014 May;38(5):615-26. doi: 10.1097/PAS.0000000000000090.2.Novel dual-color immunohistochemical methods for detecting ERG-PTEN and ERG-SPINK1 status in prostate carcinoma.Bhalla R, Kunju LP, Tomlins SA, Christopherson K, Cortez C, Carskadon S, Siddiqui J, Park K, Miguel Mosquera J, Pestano GA, Rubin MA, Chinnaiyan AM, Palanisamy NMod Pathol. 2013 Jan 25. doi: 10.1038/modpathol.2012.234.3.Loss of SPINK1 expression is associated with unfavorable outcomes in urothelial carcinoma of the bladder after radical cystectomy.Rink M, Park K, Volkmer BG, Xylinas E, Hansen J, Cha EK, Robinson BD, Hautmann R, Kufer R, Engel O, Chun FK, Dahlem R, Rubin MA, Shariat SF, Mosquera JM.Urol Oncol. 2012 Sep 1. pii: S1078-1439(12)00237-2. doi: 10.1016/j.urolonc.2012.06.011.4.325 DIFFERENCES IN TMPRSS2-ERG GENE FUSION AND SPINK1 OVEREXPRESSION IN PROSTATE CANCER IN AFRICAN-AMERICAN AND CAUCASIAN MEN.Khani F, Mosquera JM, Park K, Srivastava A, Tewari A, Rubin M, Robinson B.The Journal of Urology Volume 187, Issue 4, Supplement, April 2012, Pages e1325.Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma.Han B, Mehra R, Suleman K, Tomlins SA, Wang L, Singhal N, Linetzky KA, Palanisamy N, Zhou M, Chinnaiyan AM, Shah RB.Mod Pathol. 2009 Sep;22(9):1176-85. Epub 2009 May 22.6.The role of SPINK1 in ETS rearrangement-negative prostate cancers.Tomlins SA, Rhodes DR, Yu J, Varambally S, Mehra R, Perner S, Demichelis F, Helgeson BE, Laxman B, Morris DS, Cao Q, Cao X, Andren O, Fall K, Johnson L, Wei JT, Shah RB, Al-Ahmadie H, Eastham JA, Eggener SE, Fine SW, Hotakainen K, Stenman UH, Tsodikov A,Cancer Cell. 2008 Jun;13(6):519-28.
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