癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SPINLW1 Antibody (monoclonal) (M02A)
Mouse monoclonal antibody raised against a partial recombinant SPINLW1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O95925 |
| Other Accession | NM_020398 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgM Kappa |
| Clone Names | 4G3 |
| Calculated MW | 15284 Da |
| Gene ID | 57119 |
|---|---|
| Other Names | Eppin, Cancer/testis antigen 71, CT71, Epididymal protease inhibitor, Protease inhibitor WAP7, Serine protease inhibitor-like with Kunitz and WAP domains 1, WAP four-disulfide core domain protein 7, EPPIN, SPINLW1, WAP7, WFDC7 |
| Target/Specificity | SPINLW1 (NP_065131, 22 a.a. ~ 133 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SPINLW1 Antibody (monoclonal) (M02A) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
REFERENCES
Variants of the EPPIN gene affect the risk of idiopathic male infertility in the Han-Chinese population. Ding X, et al. Hum Reprod, 2010 Jul. PMID 20488803.Variants in the Eppin gene show association with semen quality in Han-Chinese population. Ding X, et al. Reprod Biomed Online, 2010 Jan. PMID 20158997.Analysis of recombinant human semenogelin as an inhibitor of human sperm motility. Mitra A, et al. Biol Reprod, 2010 Mar. PMID 19889947.The effect of anti-eppin antibodies on ionophore A23187-induced calcium influx and acrosome reaction of human spermatozoa. Zhang J, et al. Hum Reprod, 2010 Jan. PMID 19801569.Molecular mechanism of epididymal protease inhibitor modulating the liquefaction of human semen. Wang ZJ, et al. Asian J Androl, 2008 Sep. PMID 18645681.
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